AUD is a highly prevalent condition in the world population that causes medical, psychological, personal, social and economic problems. The most severe dimension of AUDs is alcohol dependence, a condition in which individuals lose control over alcohol intake despite the negative consequences.Although some medications have been approved for this purpose, existing pharmacotherapies are not effective for all people due to the heterogeneity of AUDs. …

During the last decades, emerging investigations have focused on the role of lipid transmitters, instead of traditional neurotransmitters, as targets for many neuropsychiatric disorders. Lipid transmitters are small molecules that are primarily generated enzymatically by the cleavage of phospholipids, which are structural components of the cell membrane. Among lipid transmitters, acylethanolamides such as OEA and palmitoylethanolamide have been s…